Postherpetic Neuralgia: Role of Gabapentin and Other Treatment Modalities
نویسندگان
چکیده
منابع مشابه
Postherpetic neuralgia: role of gabapentin and other treatment modalities.
Postherpetic neuralgia (PHN) is a chronic and painful condition that may occur after a herpes zoster infection. The frequency of PHN after untreated zoster varies widely. Age is the most important risk factor for development of PHN. The condition occurs in an estimated 50% of patients older than 50 years. The pain of PHN can be severe and debilitating and is frequently associated with allodynia...
متن کاملTreatment of postherpetic neuralgia.
Herpes zoster, a commonly seen condition in daily medical practice, is reported to occur in 10–20% of the population at some time during the lifespan. Chronic, intractable postherpetic neuralgia, a sequela of herpes zoster, presents a clinical challenge. In recent years, effective antiviral agents that can be used in the outpatient setting have been developed for the treatment of herpes zoster ...
متن کاملTolerability and safety of gastroretentive once-daily gabapentin tablets for the treatment of postherpetic neuralgia
OBJECTIVE An immediate-release formulation of gabapentin is approved for treatment of postherpetic neuralgia (PHN). This formulation, however, requires multiple daily dosing, usually three times per day, and is associated with a high incidence of somnolence and dizziness. We assessed the tolerability and safety of a once-daily gastroretentive formulation of gabapentin (G-GR) in phase 3 clinical...
متن کاملRelationships Among Adverse Events, Disease Characteristics, and Demographics in Treatment of Postherpetic Neuralgia With Gastroretentive Gabapentin
OBJECTIVES To characterize risk factors for occurrence of adverse events (AEs) and treatment discontinuations due to AEs for improving safety and tolerability of treatment of postherpetic neuralgia (PHN). METHODS Patients with PHN (n=556) received 1800 mg once-daily gastroretentive gabapentin (G-GR) in 2 phase 3 and 1 phase 4 study. Safety assessments included the incidence and severity of AE...
متن کاملTreatment and prevention of postherpetic neuralgia.
There have been 4 recent major advances in the treatment of postherpetic neuralgia (PHN) that are based on the results of randomized, controlled trials. These advances are the demonstrations that gabapentin, the lidocaine patch 5%, and opioid analgesics are efficacious in patients with PHN, and the report that nortriptyline and amitriptyline provide equivalent analgesic benefits for patients wi...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 1999
ISSN: 0013-9580,1528-1167
DOI: 10.1111/j.1528-1157.1999.tb00933.x